Parameter Set Neuroleptics 1/EXTENDED - LC/MS-MS

Parameter Set Neuroleptics 1/EXTENDED - LC/MS-MS

  • 9-OH-risperidone
  • Aripiprazole
  • Clozapine
  • Dehydroaripiprazole
  • Haloperidol
  • N-Desmethylclozapine
  • N-Desmethylolanzapine
  • Norquetiapine
  • Olanzapine
  • Quetiapine
  • Risperidone

Order no.: 92912/XT/RUO, 92111/RUO, 92110/RUO

Encompasses 11 analytes
3PLUS1® Multilevel Calibrator Set available
Part of the modular system of the Series A

Product Name Qty
Mass Tox® Neuroleptics 1/EXTENDED
Order no.: 92912/XT/RUO
BASIC Kit A for 200 tests - LC-MS/MS
Order no.: 92111/200/RUO
BASIC Kit A for 1000 tests - LC-MS/MS
Order no.: 92111/1000/RUO
MassTox® MasterColumn® A
Order no.: 92110/RUO


The modular system MassTox® BASIC Kit A in combination with the MassTox® PARAMETER Set for Neuroleptics 1/EXTENDED allows for the fast quantitative determination of aripiprazole, dehydroaripiprazole, clozapine, N-desmethylclozapine, haloperidol, olanzapine, N-desmethylolanzapine, quetiapine, norquetiapine, risperidone and 9-OH-risperidone in serum/plasma by LC-MS/MS. The use of stable isotopically marked and co-eluating internal standards ensures high performance of the analysis method.


Technical Data

Method of Analysis



9-OH-risperidone, Aripiprazole, Clozapine, Dehydroaripiprazole, Haloperidol, N-Desmethylclozapine, N-Desmethylolanzapine, Norquetiapine, Olanzapine, Quetiapine, Risperidone

Analysis Time

3 min



Sample Preparation

  • Reconstitute the Internal Standard Mix.
  • Add 800 μl Internal Standard Mix to 12 ml Precipitation Reagent to form mixture A.
  • Pipette 50 μl research sample/calibrator/MassCheck® control into a 1.5 ml reaction vial.
  • Add 25 μl Extraction Buffer.
  • Mix and incubate 2 min at ambient temperature (do not centrifuge).
  • Add 250 μl of mixture A and mix 30 s minimum (vortex).
  • Centrifuge 5 min at 15000 x g.
  • Dilute the supernatant with Dilution Buffer prior to injection depending on the instrument sensitivity.

Sample Stability

Research samples are stable for at least 24 hours when stored in the dark at +4°C. For longer storage periods keep samples frozen below -18°C.

Injection Volume

0.2 – 50 µl


0.00 - 0.20 min    20 % Mobile Phase 2
0.21 - 0.70 min    50 % Mobile Phase 2
0.71 - 2.30 min    70 % Mobile Phase 2
2.31 - 3.00 min    20 % Mobile Phase 2





Additional Info

We recommend to set the scan time to a value that allows to achieve a minimum of 10 data points over the whole peak width.

Please note

The freely available information on this website, in particular on the sample preparation, are not sufficient to work with our products. Please read instructions and warning notices on products and/or instruction manuals.

Kit Components


Calibrators available separately