Mass Tox® Neuroleptics 1/EXTENDED

Mass Tox® Neuroleptics 1/EXTENDED

Order no.: 92912/XT/RUO
  • 9-OH-risperidone
  • Aripiprazole
  • Clozapine
  • Dehydroaripiprazole
  • Haloperidol
  • N-Desmethylclozapine
  • N-Desmethylolanzapine
  • Norquetiapine
  • Olanzapine
  • Quetiapine
  • Risperidone

Encompasses 11 analytes
3PLUS1® Multilevel Calibrator Set available
Part of the modular system of the Series A


The modular system MassTox® BASIC Kit A in combination with the MassTox® PARAMETER Set for Neuroleptics 1/EXTENDED allows for the fast quantitative determination of aripiprazole, dehydroaripiprazole, clozapine, N-desmethylclozapine, haloperidol, olanzapine, N-desmethylolanzapine, quetiapine, norquetiapine, risperidone and 9-OH-risperidone in serum/plasma by LC-MS/MS. The use of stable isotopically marked and co-eluating internal standards ensures high performance of the analysis method.

For the analysis you require the MassTox® Basic Kit A, the specifc MassTox® Parameter Set and the analytical column MassTox® MasterColumn® A.


Technical Data

Method of Analysis



9-OH-risperidone, Aripiprazole, Clozapine, Dehydroaripiprazole, Haloperidol, N-Desmethylclozapine, N-Desmethylolanzapine, Norquetiapine, Olanzapine, Quetiapine, Risperidone

Analysis Time

3 min



Sample Preparation

  • Reconstitute the Internal Standard Mix.
  • Add 800 μl Internal Standard Mix to 12 ml Precipitation Reagent to form mixture A
  • Pipette 50 μl research sample/calibrator/MassCheck® control into a 1.5 ml reaction vial
  • Add 25 μl Extraction Buffer, mix briefly (vortex) and incubate 2 min.
  • Add 250 μl of mixture A and mix 30 s minimum (vortex) and centrifuge 5 min.
  • Dilute the supernatant with Dilution Buffer prior to injection depending on the instrument sensitivity

Sample Stability

Stability of research samples depends on the specific analyte. Further information can be optained from the instruction manual.

Injection Volume

0.2 – 50 µl


0.00 - 0.20 min    20 % Mobile Phase 2
0.21 - 0.70 min    50 % Mobile Phase 2
0.71 - 2.30 min    70 % Mobile Phase 2
2.31 - 3.00 min    20 % Mobile Phase 2





Additional Info

We recommend to set the scan time to a value that allows to achieve a minimum of 10 data points over the whole peak width.

Please note

The freely available information on this website, in particular on the sample preparation, are not sufficient to work with our products. Please read instructions and warning notices on products and/or instruction manuals.

Kit Components


Calibrators available separately