0249XT 0250XT 0251XT LCMS TDM Series A controls antiepileptic drugs

MassCheck® Antiepileptic Drugs/EXTENDED Plasma Controls

   
  • 10,11-Dihydroxycarbamazepine
  • 10-OH-carbamazepine
  • Brivaracetam
  • Carbamazepine
  • Carbamazepine-10,11-epoxide
  • Ethosuximide
  • Felbamate
  • Gabapentin
  • Lacosamide
  • Lamotrigine
  • Levetiracetam (Keppra®)
  • N-Desmethylmesuximide
  • Oxcarbamazepine
  • Perampanel
  • Phenobarbital
  • Phenylethylmalonamide (PEMA)
  • Pregabalin
  • Primidone
  • Retigabine
  • Rufinamide
  • Stiripentol
  • Sultiame
  • Theophylline
  • Tiagabine
  • Topiramate
  • Valproic acid
  • Zonisamide

Order no.: 0249/XT, 0250/XT, 0251/XT

Product Name Qty
MassCheck® Antiepileptic Drugs/EXTENDED Plasma Control, Bi-Level (I+II)
Order no.: 0249/XT
MassCheck® Antiepileptic Drugs/EXTENDED Plasma Control, Level I
Order no.: 0250/XT
MassCheck® Antiepileptic Drugs/EXTENDED Plasma Control, Level II
Order no.: 0251/XT

Description

MassCheck® Antiepileptic Drugs/EXTENDED Plasma Controls, lyophilised:

  • 0249/XT MassCheck® Antiepileptic Drugs/EXTENDED Plasma Control, Bi-Level I + II (lyoph.), 2 x 5 x 1 ml
  • 0250/XT MassCheck® Antiepileptic Drugs/EXTENDED Plasma Control, Level I (lyoph.), 5 x 1 ml
  • 0251/XT MassCheck® Antiepileptic Drugs/EXTENDED Plasma Control, Level II (lyoph.), 5 x 1 ml

 

These lyophilised quality controls from Chromsystems are based on human plasma and should be used according to the instruction manual. They are designed to monitor the accuracy and precision of analytical procedures in clinical diagnostics for the quantitative determination of antiepileptic drugs in serum/plasma. While following the instructions the controls should be handled and measured in the same manner as a patient specimen.

Technical Data

Method of Analysis

LC-MS/MS

Parameter

10,11-Dihydroxycarbamazepine, 10-OH-carbamazepine, Brivaracetam, Carbamazepine, Carbamazepine-10,11-epoxide, Ethosuximide, Felbamate, Gabapentin, Lacosamide, Lamotrigine, Levetiracetam (Keppra®), N-Desmethylmesuximide, Oxcarbamazepine, Perampanel, Phenobarbital, Phenylethylmalonamide (PEMA), Pregabalin, Primidone, Retigabine, Rufinamide, Stiripentol, Sultiame, Theophylline, Tiagabine, Topiramate, Valproic acid, Zonisamide

Concentrations

Please note: Concentration values shown here are typical. For lot specific concentration values please refer to the product insert supplied with the materials. The product inserts can also be requested from us directly or downloaded from our website after login.

Substance

Target value

Level I

Target range

Level I

Target value

Level II

Target range

Level II

10-OH-Carbamazepine

7.80

6.24-9.36

33.9

27.1-40.7

Carbamazepine

3.17

2.54-3.8

10.6

8.48-12.7

Carbamazepine-10.11-epoxide

1.14

0.912-1.37

7.68

6.14-9.22

Carbamazepine-Diol

0.978

0.782-1.17

8.34

6.67-10

Oxcarbazepine

0.402

0.322-0.482

2.81

2.25-3.37

Felbamate

25.1

20.1-30.1

89.3

71.4-107

Lacosamide

1.84

1.47-2.21

8.28

6.62-9.94

Lamotrigine

3.21

2.57-3.85

12.7

10.2-15.2

Levetiracetam

16.6

13.3-19.9

68.3

54.6-82

Rufinamide

7.83

6.26-9.4

25.8

20.6-31

Theophylline

9.38

7.5-11.3

18.8

15-22.6

Gabapentin

4.13

3.3-4.96

19.4

15.5-23.3

Pregabalin

1.15

0.92-1.38

8.91

7.13-10.7

Sultiame

1.71

1.37-2.05

11.1

8.88-13.3

Tiagabine (in µg/l)

34.9

27.9-41.9

170

136-204

Topiramate

3.04

2.43-3.65

21.4

17.1-25.7

Vigabatrin

5.35

4.28-6.42

30.7

24.6-36.8

N-Desmethylmesuximide

12.6

10.1-15.1

35.0

28-42

PEMA

2.09

1.67-2.51

8.28

6.62-9.94

Phenytoin

6.00

4.8-7.2

17.4

13.9-20.9

Primidone

5.19

4.15-6.23

14.1

11.3-16.9

Stiripentol

5.57

4.46-6.68

18.2

14.6-21.8

Ethosuximide

33.2

26.6-39.8

81.6

65.3-97.9

Phenobarbital

12.0

9.6-14.4

40.5

32.4-48.6

Valproic acid

43.3

34.6-52

87.7

70.2-105

Zonisamide

8.53

6.82-10.2

36.9

29.5-44.3

Brivaracetam

0.973

0.778-1.17

3.80

3.04-4.56

Perampanel (in µg/l)

175

140-210

1213

970-1456

Retigabine (in µg/l)

243

194-292

1786

1429-2143

Reconstitution

Carefully remove the rubber stopper from the vials. Add exactly 1.0 ml of distilled water into each vial. Return the stopper and incubate for 10 to 15 minutes at room temperature. Swirl the vials to dissolve the contents until homogeneity.

Storage conditions

Stored below -18 °C and unopened, the lyophilised controls are stable until the expiry date specified on the vial labels. The reconstituted controls can be stored up to 2 weeks light protected and tightly capped at +2 to +8 C. If the controls cannot be used within this period, they should be aliquoted and stored frozen below -18 °C (up to 3 months). For more details about storage conditions please check your instruction manual.