0261 0262 0263 LCMS TDM Series A controls anti-HIV drugs

MassCheck® Anti-HIV Drugs Plasma Controls

   
  • Amprenavir
  • Atazanavir
  • Darunavir
  • Delavirdine
  • Efavirenz
  • Elvitegravir
  • Etravirine
  • Indinavir
  • Lopinavir
  • Maraviroc
  • Nelfinavir
  • Nelfinavir-M8
  • Nevirapine
  • Raltegravir
  • Rilpivirine
  • Ritonavir
  • Tipranavir

Order no.: 0261/0262/0263

Product Name Qty
MassCheck® Anti-HIV Drugs Plasma Control, Level I
Order no.: 0262
MassCheck® Anti-HIV Drugs Plasma Control, Level II
Order no.: 0263
MassCheck® Anti-HIV Drugs Plasma Control, Bi-Level (I+II)
Order no.: 0261

Description

MassCheck® Anti-HIV Drugs Plasma Controls, lyophilised

0261 MassCheck® Anti-HIV Drugs Plasma Control, Bi-Level I + II (lyoph.), 2 x 5 x 1 ml
0262 MassCheck® Anti-HIV Drugs Plasma Control, Level I (lyoph.), 5 x 1 ml
0263 MassCheck® Anti-HIV Drugs Plasma Control, Level II (lyoph.), 5 x 1 ml

These lyophilised quality controls from Chromsystems are based on human plasma and should be used according to the instruction manual. They are designed to monitor the accuracy and precision of analytical procedures in clinical diagnostics for the quantitative determination of anti-HIV drugs in serum/plasma. While following the instructions the controls should be handled and measured in the same manner as a patient specimen.

Technical Data

Method of Analysis

LC-MS/MS

Parameter

Amprenavir, Atazanavir, Darunavir, Delavirdine, Efavirenz, Elvitegravir, Etravirine, Indinavir, Lopinavir, Maraviroc, Nelfinavir, Nelfinavir-M8, Nevirapine, Raltegravir, Rilpivirine, Ritonavir, Tipranavir

Concentrations

Please note: Concentration values shown here are typical. For lot specific concentration values please refer to the product insert supplied with the materials. The product inserts can also be requested from us directly or downloaded from our website after login.

SubstanceValue [µg/l]
Level I
Range [µg/l]
Level I
Value [µg/l]
Level II
Range [µg/l]
Level II
Group 1
Amprenavir 488 391-586 2026 1620-2431
Darunavir 507 406-609 3972 3178-4766
Delavirdine 1633 1306-1960 7455 5964-8946
Maraviroc 128 102.7-154 876 701-1051
Nevirapine 2901 2320-3481 5668 4534-6801
Raltegravir 91.5 73.2-109.8 450 360-540
Group 2
Efavirenz 1132 906-1358 3469 2775-4162
Indinavir 300 240-360 2572 2058-3086
Nelfinavir 863 690-1035 2058 1646-2469
M8-Nelfinavir 325 260-390 1271 1017-1525
Rilpivirine 77.4 61.9-92.9 287 230-344
Saquinavir 121 97.1-146 689 551-827
Group 3
Atazanavir 324 259-389 2189 1751-2627
Elvitegravir 256 205-308 906 725-1087
Etravitrine 390 312-468 2654 2123-3185
Lopinavir 1854 1483-2225 8266 6612-9919
Ritonavir 1350 1080-1620 9521 7617-11425
Tipranavir 14317 11454-17180 39851 31881-47821

Reconstitution

Carefully remove the metal seal and rubber stopper from the vials. Add exactly 1.0 ml of distilled water into each vial. Return the stopper and incubate for 10 to 15 minutes at room temperature. Swirl the vials to dissolve the contents until homogeneity.

Storage conditions

Stored below -18 °C and unopened, the lyophilised controls are stable until the expiry date specified on the vial labels. The reconstituted controls can be stored in glass containers up to 2 weeks light protected and tightly capped at +2 to +8 C. If the controls cannot be used within this period, they should be aliquoted and stored frozen below -18 °C (up to 3 months). For more details about storage conditions please check your instruction manual.