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Description
3PLUS1® Multilevel Calibrator Set for the Parameter Set Neuroleptics 1/EXTENDED, lyophilised
These lyophilised calibrators from Chromsystems are based on human plasma and should be used according to the instruction manual. They are designed to calibrate the measurement method for the quantitative determination of neuroleptics 1/Extended. While following the instructions the calibrators should be handled and measured in the same manner as research samples.
These calibrators are only available as multilevel calibrator set with 3 different concentration levels plus 1 blank value.
Technical Data
Method of Analysis
LC-MS/MS
Content
4 x 1 ml (lyoph.)
Parameter
9-OH-risperidone, Aripiprazole, Clozapine, Dehydroaripiprazole, Haloperidol, N-Desmethylclozapine, N-Desmethylolanzapine, Norquetiapine, Quetiapine, Risperidone
Concentrations
Please note: Concentration values shown here are typical. For lot specific concentration values please refer to the product insert supplied with the materials. The product inserts can also be requested from us directly.
| Substance | Calibrator 1 (µg/l) | Calibrator 2 (µg/l) | Calibrator 3 (µg/l) | Blank Calibrator (µg/l) |
|---|---|---|---|---|
| Aripiprazole | 20.4 | 246 | 701 | n.d. |
| Dehydroaripiprazole | 7.87 | 91.8 | 256 | n.d. |
| Clozapine | 76.0 | 453 | 1226 | n.d. |
| N-Desmethylclozapine | 77.0 | 202 | 464 | n.d. |
| Haloperidol | 1.82 | 14.1 | 27.0 | n.d. |
| Olanzapine | 3.83 | 50.3 | 142 | n.d. |
| N-Desmethylolanzapine | 3.42 | 48.6 | 141 | n.d. |
| Quetiapine | 27.0 | 203 | 556 | n.d. |
| Norquetiapine | 10.3 | 74.7 | 206 | n.d. |
| Risperidone | 2.07 | 12.4 | 30.9 | n.d. |
| 9-OH-Risperidone | 3.90 | 51.6 | 142 | n.d. |
n.d. = not detected
The blank level is manufactured using the same matrix pool as used for the calibrator levels 1, 2 and 3. It was not fortified with any neuroleptics.
Reconstitution
Carefully remove the metal seal and rubber stopper from the vials. Add exactly 1.0 ml of distilled water into each vial. Return the stopper and incubate for 10 to 15 minutes at room temperature. Swirl the vials to dissolve the contents until homogeneity.
Storage conditions
Stored below -18 °C and unopened, the lyophilised calibrators are stable until the expiry date specified on the vial labels. The reconstituted calibrators can be stored in glass containers up to 3 days light protected and tightly capped at +2 to +8 C. If the calibrators cannot be used within this period, they should be aliquoted and stored frozen below -18 °C (up to 3 months). For more details about storage conditions please check your instruction manual.
