3PLUS1® Multilevel Plasma Calibrator Set Imatinib/Norimatinib/Dasatinib/Nilotinib

3PLUS1® Multilevel Plasma Calibrator Set Imatinib/Norimatinib/Dasatinib/Nilotinib

Order no.: 58028
  • Dasatinib
  • Imatinib
  • Nilotinib
  • Norimatinib
 

Description

3PLUS1® Multilevel Plasma Calibrator Set Imatinib/Norimatinib/Dasatinib/Nilotinib, lyophilised

These lyophilised calibrators from Chromsystems are based on human plasma and should be used according to the instruction manual. They are designed to calibrate the measurement method in clinical diagnostics for the quantitative determination of imatinib, norimatinib, dasatinib and nilotinib in serum/plasma. While following the instructions the calibrators should be handled and measured in the same manner as a patient specimen.
These calibrators are only available as multilevel calibrator set with 3 different concentration levels plus 1 blank value.

Technical Data

Method of Analysis

HPLC

Content

4 x 2 ml (lyoph.)

Parameter

Dasatinib, Imatinib, Nilotinib, Norimatinib

Concentrations

Please note: Concentration values shown here are typical. For lot specific concentration values please refer to the product insert supplied with the materials. The product inserts can also be requested from us directly or downloaded from our website after login.

Calibration levelSubstanceUnitValue
Calibrator 1 Imatinib µg/l
nmol/l
487
987
  Norimatinib µg/l
nmol/l
106
221
  Dasatinib µg/l
nmol/l
79
162
  Nilotinib µg/l
nmol/l
480
906
Calibrator 2 Imatinib µg/l
nmol/l
1408
2853
  Norimatinib µg/l
nmol/l
263
548
  Dasatinib µg/l
nmol/l
194
398
  Nilotinib µg/l
nmol/l
951
1796
Calibrator 3 Imatinib µg/l
nmol/l
2399
4860
  Norimatinib µg/l
nmol/l
428
892
  Dasatinib µg/l
nmol/l
315
645
  Nilotinib µg/l
nmol/l
1428
2697
Blank Calibrator Imatinib µg/l
nmol/l
n.d.
n.d.
  Norimatinib µg/l
nmol/l
n.d.
n.d.
  Dasatinib µg/l
nmol/l
n.d.
n.d.
  Nilotinib µg/l
nmol/l
n.d.
n.d.

n.d. = not detected

The blank level is manufactured using the same matrix pool as used for the calibrator levels 1-3. It was not fortified.

Reconstitution

Carefully remove the metal seal and rubber stopper from the vials. Add exactly 2.0 ml of distilled water into each vial. Return the stopper and incubate for 10 to 15 minutes at room temperature. Swirl the vials to dissolve the contents until homogeneity.

Storage conditions

Stored below -18 °C and unopened, the lyophilised calibrators are stable until the expiry date specified on the vial labels. The reconstituted calibrators can be stored up to 3 weeks tightly capped at +2 to +8 C. If the calibrators cannot be used within this period, they should be aliquoted and stored frozen below -18 °C (up to 3 months). For more details about storage conditions please check your instruction manual.