3PLUS1® Multilevel Plasma Calibrator Set Antidepressants 2/ Psychostimulants/EXTENDED

3PLUS1® Multilevel Plasma Calibrator Set Antidepressants 2/ Psychostimulants/EXTENDED

Order no.: 92027/XT
  • Atomoxetine
  • Bupropion
  • Clomethiazole
  • Dosulepin
  • erythro-Dihydrobupropion
  • Hydroxybupropion
  • Methylphenidate
  • Mianserin
  • Milnacipran
  • Moclobemide
  • N-Desmethyldosulepin
  • Opipramol
  • Reboxetine
  • Ritalinic acid
  • threo-Dihydrobupropion
  • Tianeptine
  • Tranylcypromine
  • Trazodone
  • Vilazodone
  • Vortioxetine
 

Description

3PLUS1® Multilevel Plasma Calibrator Set, lyophilised.

These lyophilised calibrators from Chromsystems are based on human plasma and should be used according to the instruction manual. They are designed to calibrate the measurement method in clinical diagnostics for the quantitative determination of antidepressants 2 and psychostimulants in serum/plasma. While following the instructions the calibrators should be handled and measured in the same manner as a patient specimen.
These calibrators are only available as multilevel calibrator set with 3 different concentration levels plus 1 blank value.

Technical Data

Method of Analysis

LC-MS/MS

Content

4 x 1 ml (lyoph.)

Parameter

Atomoxetine, Bupropion, Clomethiazole, Dosulepin, erythro-Dihydrobupropion, Hydroxybupropion, Methylphenidate, Mianserin, Milnacipran, Moclobemide, N-Desmethyldosulepin, Opipramol, Reboxetine, Ritalinic acid, threo-Dihydrobupropion, Tianeptine, Tranylcypromine, Trazodone, Vilazodone, Vortioxetine

Concentrations

Please note: Concentration values shown here are typical. For lot specific concentration values please refer to the product insert supplied with the materials. The product inserts can also be requested from us directly or downloaded from our website after login.

Clomethiazole

Substance Calibrator 1
(µg/l)
Calibrator 2
(µg/l)
Calibrator 3
(µg/l)
Blank Calibrator
(µg/l)
Atomoxetine 23.7 638 1204 n.d. (<2.58)
Clomethiazole 56.4 2509 4796 n.d. (<19.4)
Dosulepin 70.0 150 228 n.d. (<8.40)
N-Desmethyldosulepin 14.2 190 364 n.d. (<3.56)
Methylphenidate 3.29 42.1 78.6 n.d. (<0.805)
Mianserin 6.92 91.6 168 n.d. (<2.23)
Milnacipran 19.6 206 368 n.d. (<5.53)
Moclobemide 154 1367 2453 n.d. (<41.4)
Opipramol 36.7 320 594 n.d. (<9.96)
Reboxetine 21.2 215 411 n.d. (<5.81)
Ritalinic Acid 27.6 189 344 n.d. (<7.22)
Tianeptine 21.1 181 350 n.d. (<11.3)
Tranylcypromine 7.53 306 615 n.d. (<5.11)
Trazodone 230 1637 2891 n.d. (<115)
Vilazodone 23.1 57.7 91.0 n.d. (<7.41)
Vortioxetine 6.92 49.8 92.8 n.d. (<4.11)
Bupropion 6.74 154 301 n.d. (<1.83)
erythro-Dihydrobupropion 6.73 148 291 n.d. (<3.90)
Hydroxybupropion 29.0 1055 2060 n.d. (<7.38)
threo-Dihydrobupropion 34.9 746 1377 n.d. (<2.70)

n.d. = not detected (< LOQ)
The blank level is manufactured using the same matrix pool as used for the calibrator levels 1, 2 and 3. It was not fortified with any drugs.

Reconstitution

Carefully remove the rubber stopper from the vials. Add exactly 1.0 ml of distilled water into each vial. Return the stopper and incubate for 10 to 15 minutes at room temperature. Swirl the vials to dissolve the contents until homogeneity.

Storage conditions

Stored below -18 °C and unopened, the lyophilised calibrators are stable until the expiry date specified on the vial labels. The reconstituted calibrators can be stored in glass containers up to 24 hours light protected and tightly capped at +2 to +8 C. If the calibrators cannot be used within this period, they should be aliquoted and stored frozen below -18 °C (up to 3 months). For more details about storage conditions please check your instruction manual.