92030 LCMS TDM Series A 3PLUS1 calibrator benzodiazepines1

3PLUS1® Multilevel Plasma Calibrator Set Benzodiazepines 1

Order no.: 92030
  • 1-OH-midazolam
  • Chlordiazepoxide
  • Clobazam
  • Demoxepam
  • Diazepam
  • Medazepam
  • Midazolam
  • Norclobazam
  • Nordiazepam
  • Oxazepam
  • Prazepam
  • Temazepam
  • Tetrazepam
Component of the Parameter Set Benzodiazepines 1, available separately

Description

3PLUS1® Multilevel Plasma Calibrator Set for the Parameter Set Benzodiazepines 1, lyophilised

These lyophilised calibrators from Chromsystems are based on human plasma and should be used according to the instruction manual. They are designed to calibrate the measurement method in clinical diagnostics for the quantitative determination of benzodiazepines 1 in serum/plasma. While following the instructions the calibrators should be handled and measured in the same manner as a patient specimen.
These calibrators are only available as multilevel calibrator set with 3 different concentration levels plus 1 blank value.

Technical Data

Method of Analysis

LC-MS/MS

Content

4 x 1 ml (lyoph.)

Parameter

1-OH-midazolam, Chlordiazepoxide, Clobazam, Demoxepam, Diazepam, Medazepam, Midazolam, Norclobazam, Nordiazepam, Oxazepam, Prazepam, Temazepam, Tetrazepam

Concentrations

Please note: Concentration values shown here are typical. For lot specific concentration values please refer to the product insert supplied with the materials. The product inserts can also be requested from us directly or downloaded from our website after login.

Substance Calibrator 1
(µg/l)
Calibrator 2
(µg/l)
Calibrator 3
(µg/l)
Blank Calibrator
(µg/l)
Chlordiazepoxide 236 1110 1992 n.d.
Clobazam 57.0 283 518 n.d.
Norclobazam 582 2388 4299 n.d.
Demoxepam 261 1268 2290 n.d.
Diazepam 72.3 892 1703 n.d.
Nordiazepam 13.5 864 1759 n.d.
Medazepam 62.8 289 534 n.d.
Midazolam 15.1 132 249 n.d.
1-OH-Midazolam 12.2 117 219 n.d.
Oxazepam 134 1183 2292 n.d.
Prazepam 124 421 689 n.d.
Temazepam 12.8 557 1150 n.d.
Tetrazepam 34.9 471 912 n.d.

n.d. = not detected (< LOQ)

The blank level is manufactured using the same matrix pool as used for the calibrator levels 1, 2 and 3. It was not fortified with any benzodiazepines.

Reconstitution

Carefully remove the metal seal and rubber stopper from the vials. Add exactly 1.0 ml of distilled water into each vial. Return the stopper and incubate for 10 to 15 minutes at room temperature. Swirl the vials to dissolve the contents until homogeneity.

Storage conditions

Stored below -18 °C and unopened, the lyophilised calibrators are stable until the expiry date specified on the vial labels. The reconstituted calibrators can be stored in glass containers up to 1 week light protected and tightly capped at +2 to +8 C. If the calibrators cannot be used within this period, they should be aliquoted and stored frozen below -18 °C (up to 3 months). For more details about storage conditions please check your instruction manual.