92029XT LCMS TDM Series A 3PLUS1 calibrator antidepressants1_XT

3PLUS1® Multilevel Plasma Calibrator Set Antidepressants 1/EXTENDED

Order no.: 92029/XT
  • Citalopram
  • Desmethylfluoxetine
  • Duloxetine
  • Fluoxetine
  • Fluvoxamine
  • Mirtazapine
  • N-Desmethylcitalopram
  • N-Desmethylmirtazapine
  • N-Desmethylsertraline
  • O-Desmethylvenlafaxine
  • Paroxetine
  • Sertraline
  • Venlafaxine
Component of the Parameter Set Antidepressants 1/EXTENDED, available separately.

Description

3PLUS1® Multilevel Plasma Calibrator Set for Antidepressants 1/EXTENDED, lyophilised

These lyophilised calibrators from Chromsystems are based on human plasma and should be used according to the instruction manual. They are designed to calibrate the measurement method in clinical diagnostics for the quantitative determination of antidepressants 1/Extended in serum/plasma. While following the instructions the calibrators should be handled and measured in the same manner as a patient specimen.
These calibrators are only available as multilevel calibrator set with 3 different concentration levels plus 1 blank value.

Technical Data

Method of Analysis

LC-MS/MS

Content

4 x 1 ml (lyoph.)

Parameter

Citalopram, Desmethylfluoxetine, Duloxetine, Fluoxetine, Fluvoxamine, Mirtazapine, N-Desmethylcitalopram, N-Desmethylmirtazapine, N-Desmethylsertraline, O-Desmethylvenlafaxine, Paroxetine, Sertraline, Venlafaxine

Concentrations

Please note: Concentration values shown here are typical. For lot specific concentration values please refer to the product insert supplied with the materials. The product inserts can also be requested from us directly or downloaded from our website after login.

Substance Calibrator 1
(µg/l)
Calibrator 2
(µg/l)
Calibrator 3
(µg/l)
Blank Calibrator
(µg/l)
Citalopram 8.16 104 292 n.d.
N-Desmethylcitalopram 9.00 114 315 n.d.
Duloxetine 2.17 85.4 164 n.d.
Fluoxetine 76.4 295 720 n.d.
Desmethylfluoxetine 117 347 774 n.d.
Fluvoxamine 39.7 160 381 n.d.
Mirtazapine 7.75 155 445 n.d.
N-Desmethylmirtazapine 8.40 162 452 n.d.
Paroxetine 23.0 67.5 146 n.d.
Sertraline 4.26 81.1 228 n.d.
N-Desmethylsertraline 11.6 132 364 n.d.
Venlafaxine 22.9 107 269 n.d.
O-Desmethylvenlafaxine 54.8 295 736 n.d.

n.d. = not detected

The blank level is manufactured using the same matrix pool as used for the calibrator levels 1, 2 and 3. It was not fortified with any antidepressants.

Reconstitution

Carefully remove the metal seal and rubber stopper from the vials. Add exactly 1.0 ml of distilled water into each vial. Return the stopper and incubate for 10 to 15 minutes at room temperature. Swirl the vials to dissolve the contents until homogeneity.

Storage conditions

Stored below -18 °C and unopened, the lyophilised calibrators are stable until the expiry date specified on the vial labels. The reconstituted calibrators can be stored up to 2 weeks light protected and tightly capped at +2 to +8 C. If the calibrators cannot be used within this period, they should be aliquoted and stored frozen below -18 °C (up to 3 months). For more details about storage conditions please check your instruction manual.

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